SANTA CLARA, Calif. — For the third straight game, the San Francisco 49ers will be without star left tackle Trent Williams as he continues to recover from a left ankle injury.

The Niners officially ruled out Williams on Friday ahead of Sunday’s matchup against the Chicago Bears. They also will be without safety George Odum (knee), linebacker Dre Greenlaw (Achilles) and running back Jordan Mason (ankle).

There is, however, at least some hope for defensive end Nick Bosa. Although Bosa did not practice this week as he recovers from left hip and oblique injuries, he showed enough signs of improvement to be listed as doubtful for Sunday, according to coach Kyle Shanahan.

Whether that’s enough to have Bosa available remains to be seen, particularly since the Niners have a short week coming with a Thursday night game against the Los Angeles Rams.

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The 49ers have struggled mightily without Bosa and Williams, arguably two of the best players in the league at their positions and undoubtedly two of the most difficult to replace on the team.

Since Williams arrived via trade in 2020, San Francisco is 49-28 when he plays and 3-8 when he doesn’t. Since Bosa arrived in 2019, the Niners are 62-28 when he plays and 5-12 when he doesn’t.